Open AccessA 21‐YEAR‐OLD FEMALE WITH ATHIRD VENTRICULAR TUMOR
Author(s) -
Hamilton Ronald L.,
MessingJünger A. Martina,
Riemenschneider Markus J.,
Reifenberger Guido
Publication year - 2006
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.2006.tb00566.x
Subject(s) - schwannoma , medicine , choroid plexus , fourth ventricle , pathology , pilocytic astrocytoma , histopathology , choroid plexus papilloma , neural crest , magnetic resonance imaging , cerebral ventricle neoplasms , third ventricle , astrocytoma , glioma , anatomy , radiology , central nervous system , biology , embryo , cancer research , microbiology and biotechnology
A 21-year-old female presented with a 2-months history of tinnitus, vertigo and nausea. On magnetic resonance imaging of the brain, she demonstrated a small contrast-enhancing mass in the posterior part of the third ventricle. Intraoperatively, the tumor showed a close relationship to the choroid plexus of the third ventricle. Histopathology revealed a benign schwannoma of World Health Organization grade I. To our knowledge, only 9 cases of intraventricular Schwann cell tumors have been published so far. Most of these tumors were benign schwannomas, except for 2 cases of malignant peripheral nerve sheath tumors. The tumor of our patient is the first reported schwannoma of the third ventricle. The origin of intraventricular Schwann cell tumors is unknown. They may arise from autonomic perivascular nerves in the choroid plexus or from ectopic neural crest-derived cells. Histologically, intraventricular schwannoma needs to be distinguished from other spindle cell tumors, in particular pilocytic astrocytoma and fibroblastic meningioma.