Open AccessCASE OF THE MONTH May 1996 ‐ Hydrocephalus in a 9 Month Old Infant
Author(s) -
Hamilton Dr. Ronald L.
Publication year - 1996
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.1996.tb00885.x
Subject(s) - hydrocephalus , citation , medicine , pediatrics , library science , psychology , surgery , computer science
A 9 month old infant presented with hydrocephalus. MRI studies revealed a large cystic space with a nodule that was bright on T-1 weighted images and dark on T-2 weighted images. It was bright with contrast enhancement. The surgical specimen was noted to be dark black. Microscopic examination revealed a benign papillary tumor consistent with a choroid plexus papilloma which was heavily pigmented with melanin. Immunohisto-chemical stains were consistent with a choroid plexus papilloma, but they also showed many epithelial cells to be positive for HMB-45. Ultrastructural studies demonstrated melanosomes and pre-melanosomes in cells with well-delineated basal lamina. This is the first case to demonstrate melanosomes in a benign choroid plexus papilloma. Previously reported cases of pigmented lesions of the choroid plexus either contained neuromelanin in the benign examples or melanosomes in two cases of choroid plexus carcinomas.