Open AccessMolecular Motors and Cell Motility in the Brain
Author(s) -
Mercer John A.,
Albanesi Joseph P.,
Brady Scott T.
Publication year - 1994
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.1994.tb00827.x
Subject(s) - axoplasm , growth cone , motility , microtubule , axoplasmic transport , microfilament , neuroscience , axon , biology , microbiology and biotechnology , motor protein , cell , nervous system , anatomy , cytoskeleton , biochemistry
The advent of video computer‐enhanced microscopy has provided a new vision of cell migrations, growth cones, and fast axonal transport in the nervous system. In images obtained in studies of fast transport in isolated axoplasm from the squid giant axon, a virtual torrent of membrane traffic could be seen moving in both directions. Similarly, examination of growth cones and cell migrations in vitro and in vivo revealed properties of cell motility that were previously unsuspected. Evidence has accumulated that many of these activities are driven by a variety of microtubule and microfilament based motors.