Open AccessSynapsin I, Synapsin II, and Synaptophysin: Marker Proteins of Synaptic Vesicles
Author(s) -
Thiel Gerald
Publication year - 1993
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.1993.tb00729.x
Subject(s) - synaptophysin , synapsin , synaptic vesicle , synapsin i , synaptotagmin 1 , neurotransmitter , vesicle , microbiology and biotechnology , neuroscience , biology , organelle , synapse , chemistry , biochemistry , membrane , central nervous system , immunohistochemistry , immunology
The nerve terminal of neurons is filled with small synaptic vesicles, specialized secretory organelles involved in the storage and release of neurotransmitters. The synapsins are a family of four proteins that are the major peripheral proteins on the cytoplasmic face of synaptic vesicles. Synaptophysin is the major integral membrane protein of synaptic vesicles. The characterization of the synapsins and of synaptophysin during the last years has revealed exciting information about their structure, regulation and possible function. To understand the role of the synapsins and synaptophysin in the biology of a nerve cell means to elucidate the fundamental mechanism of brain function, the release of neurotransmitter.