Open AccessInteraction of T Lymphocytes with Cerebral Endothelial Cells in vitro
Author(s) -
Wekerle Hartmut,
Engelhardt Britta,
Risau Werner,
Meyermann Richard
Publication year - 1991
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.1991.tb00647.x
Subject(s) - homing (biology) , blood–brain barrier , antigen , central nervous system , immune system , lymphocyte homing receptor , immunology , in vitro , inflammation , neuroscience , biology , antigen presentation , medicine , pathology , t cell , cell , cell adhesion , ecology , biochemistry , genetics
As a prerequisite of inflammatory lesion formation in (auto‐)immune disease of the central nervous system, lymphocytes have to interact with brain endo‐thelia. In recent years much progress has been made towards a better understanding of mechanisms and factors involved in organ specific homing of lymphocytes. Many lines of evidence indicate that T lymphocytes recognizing antigens which are exclusively beyond the blood‐brain barrier cross this barrier only when they are in an activated state, irrespective of their antigen specificity. Antigen presentation by blood‐brain barrier endothelia, however, may play a role in later stages of florid inflammation.