Open AccessNeurotropic Herpesviruses, Neural Mechanisms and Arteritis
Author(s) -
Martin John R.,
Mitchell William J.,
Henken Deborah B.
Publication year - 1990
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.1990.tb00631.x
Subject(s) - arteritis , pathogenesis , neuroscience , virus , medicine , virology , varicella zoster virus , immunology , biology , pathology
Cumulative evidence suggests that varicella‐zoster virus (VZV) can infect walls of CNS arteries, causing stroke in man. We review observations relating infection with this neurotropic virus to the development of arteritis in the CNS and note evidence supporting the hypothesis that VZV spreads from ganglionic reactivation sites to the arterial wall by neural pathways. Problems relating to the pathogenesis of arteritis and experimental approaches to their solution are suggested.