Open AccessViral load at diagnosis and influenza A H1N1 (2009) disease severity in children
Author(s) -
Launes Cristian,
GarciaGarcia Juan J.,
Jordan Iolanda,
Selva Laura,
Rello Jordi,
MuñozAlmagro Carmen
Publication year - 2012
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/j.1750-2659.2012.00383.x
Subject(s) - medicine , viral load , mechanical ventilation , severity of illness , disease , biomarker , pediatrics , covid-19 , emergency medicine , virus , infectious disease (medical specialty) , immunology , biochemistry , chemistry
Please cite this paper as: Launes et al. (2012) Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children. Influenza and Other Respiratory Viruses 6(601), e89–e92. To assess viral load at diagnosis (VLAD) as a biomarker of novel influenza disease severity, epidemiologic and clinical data of admitted patients <18 years old with Influenza A H1N1 (2009) infection and respiratory symptoms were prospectively collected in a single pediatric tertiary hospital, from weeks 30–51 of 2009. Seventy patients were included. VLAD in children who had symptoms for ≥5 days was an accurate parameter distinguishing the patients who required mechanical ventilation (MV) from those who did not required it (area under the ROC curve: 0·73; P = 0·03). Having <4·5 log10 copies/ml with ≥5 days of symptoms was associated with a lower risk of requiring MV.