Open AccessLiver involvement during influenza infection: perspective on the 2009 influenza pandemic
Author(s) -
Papic Neven,
Pangercic Ana,
Vargovic Martina,
Barsic Bruno,
Vince Adriana,
Kuzman Ilija
Publication year - 2012
Publication title -
influenza and other respiratory viruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.743
H-Index - 57
eISSN - 1750-2659
pISSN - 1750-2640
DOI - 10.1111/j.1750-2659.2011.00287.x
Subject(s) - pandemic , lactate dehydrogenase , alanine transaminase , alkaline phosphatase , immunology , aspartate transaminase , alanine aminotransferase , influenza a virus subtype h5n1 , immune system , transaminase , medicine , biology , virology , covid-19 , virus , enzyme , infectious disease (medical specialty) , disease , biochemistry
Please cite this paper as: Papic et al. (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5. Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.