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Nuclear matrix protein 22 is superior to voided urine cytology
Author(s) -
Turner Bruce,
Baithun Suhail,
Grey Alistair,
Pati Jhumur
Publication year - 2010
Publication title -
international journal of urological nursing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.184
H-Index - 8
eISSN - 1749-771X
pISSN - 1749-7701
DOI - 10.1111/j.1749-771x.2010.01087.x
Subject(s) - medicine , urine cytology , urine , cytology , predictive value , urology , urinary system , cancer , gynecology , pathology , bladder cancer
Patients with microscopic and macroscopic haematuria undergo a series of investigations to assess the upper and lower urinary tracts. The authors recently demonstrated that urine cytology is an unnecessary expense in the evaluation of haematuria as it slows the patient pathway, is expensive and has a sensitivity of only 41%. The aim of this article is to evaluate the role of the nuclear matrix protein (NMP) 22 urine test as an alternative to urine cytology. The results of 219 patients who completed investigations for haematuria were evaluated: NMP 22 was positive in 26 patients. Cancer was confirmed in 17 of the 219 patients. NMP 22 was negative and cancer excluded in 188 patients. Of the 17 patients with cancer, 12 had a positive NMP 22 test and 5 had a negative NMP 22. Of the 26 patients with a positive NMP 22, 14 were found not to have cancer. This equates to an overall positive predictive value of 46·1%, negative predictive value of 97·4%, sensitivity of 70% and a specificity of 93% which shows that NMP 22 is superior to urine cytology in the investigation of adult haematuria, particularly with a negative predictive value of 97%.