Open AccessTissue Distribution of Enrofloxacin in Fingerling Rainbow Trout Oncorhynchus mykiss Following Different Doses of Oral Administration
Author(s) -
Hsu HuiMin,
Wooster Gregory A.,
Bowser Paul R.
Publication year - 1994
Publication title -
journal of the world aquaculture society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 60
eISSN - 1749-7345
pISSN - 0893-8849
DOI - 10.1111/j.1749-7345.1994.tb00822.x
Subject(s) - enrofloxacin , rainbow trout , biology , aeromonas salmonicida , zoology , antibiotics , veterinary medicine , fishery , fish <actinopterygii> , microbiology and biotechnology , medicine , ciprofloxacin
Rainbow trout Oncorhynchus mykiss were fed a ration medicated to provide enrofloxacin (Baytrilo®, Bayer) at 2.5, 5.0, or 10.0 mg drug per kg fish per d either 5 or 10 d. Tissue Concentrations of enrofloxacin were measured in liver, kidney, muscle, skin, and serum during the medication period, and thereafter for a total of 30 d. Highest tissue concentrations were observed in fish medicated with 5 mg enrofloxacin per kg fish per d for 10 d. Tissue concentrations of anitmicrobial activity were found to exceed minimum inhibitory concentrations of enrofloxacin for several isolates of Aeromonas salmonicida and Renibacterium salmoninarum . Lower than expected tissue concentrations were observed for the 10 mg per kg fish per d doses, perhaps due to a lack of acceptance of the medicated ration. The results support evaluation of a 5 mg per kg fish dose to treat bacterial infections of salmonids under field conditions.