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The Myasthenia Gravis‐Specific Activities of Daily Living Profile
Author(s) -
Muppidi Srikanth
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06817.x
Subject(s) - myasthenia gravis , activities of daily living , rasch model , medicine , physical therapy , quality of life (healthcare) , psychology , developmental psychology , nursing
The myasthenia gravis activities of daily living (MG‐ADL) profile is an eight‐item patient‐reported scale developed to assess MG symptoms and their effects on daily activities. The MG‐ADL profile correlated well with the Quantitative MG (QMG) score ( r = 0.58, P < 0.001) in 254 consecutive patient visits. Further analysis during clinical trials confirmed the excellent correlation with the QMG test and provided additional evidence that the MG‐ADL profile is responsive to clinical improvement. MG‐ADL performance was further analyzed during a recent multicenter, prospective scale validation study for two new outcome measures. At the first visit, there was a strong positive correlation between the MG‐ADL and the MG Composite ( r = 0.85, P < 0.0001) and between the MG‐ADL and the MG‐Quality of life15 (MG‐QOL15) ( r = 0.76, P < 0.0001). Test–retest analysis demonstrated a high reliability coefficient. Sensitivity/specificity analysis revealed that a 2‐point improvement has the best trade‐off attributes to predict clinical improvement. The MG‐ADL profile also performed well on Rasch analysis. The MG‐ADL scoring system is useful as a secondary outcome measure and in routine clinical management.