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Thymus pathology observed in the MGTX trial
Author(s) -
Marx Alexander,
Pfister Frederik,
Schalke Berthold,
Nix Wilfred,
Ströbel Philipp
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06799.x
Subject(s) - thymectomy , myasthenia gravis , prednisone , medicine , grading (engineering) , involution (esoterism) , hyperplasia , pathology , biology , ecology , consciousness , neuroscience
The MGTX trial is the first prospective, randomized clinical trial that aims to evaluate the impact of extended transsternal thymectomy on myasthenic symptoms, prednisone requirements, and quality of life in patients with nonthymomatous, anti‐acetylcholine receptor autoantibody‐positive myasthenia gravis (MG). Here, we give an overview of the rationale of thymectomy and the standardized macroscopic and histopathological work‐up of thymectomy specimens as fixed in MGTX standard operating procedures, including the grading of thymic lymphofollicular hyperplasia and the morphometric strategy to assess thymic involution.