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Selection of possible responders to thrombolytic therapy in acute ischemic stroke
Author(s) -
Hametner Christian,
Ringleb Peter Arthur,
Hacke Werner,
Kellert Lars
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06747.x
Subject(s) - medicine , stroke (engine) , intensive care medicine , clinical trial , ischemic stroke , selection (genetic algorithm) , acute stroke , ischemia , tissue plasminogen activator , mechanical engineering , artificial intelligence , computer science , engineering
Ischemic stroke is one of the leading causes of death and morbidity worldwide, and systemic thrombolytic treatment is still the first‐line therapy within 4.5 h from symptom onset. Selecting patients for treatment response is mandatory in any time window but challenging as well. The authors aim to support stroke physicians in their individual decision making. Besides evidence from clinical trials, some suggestions included here exclusively reflect the authors' opinions. This article presents clinical and imaging criteria of selecting patients reasonably, offering causal therapy to a growing number of patients.