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The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells
Author(s) -
Cabrera Carlos,
Carriquiry Gabriela,
Pierinelli Chiara,
Reinoso Nancy,
AriasStella Javier,
Paino Javier
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06727.x
Subject(s) - mesenchymal stem cell , regeneration (biology) , umbilical cord , wound healing , stem cell , microbiology and biotechnology , biological activity , secretion , chemistry , regenerative medicine , pharmacology , medicine , biology , immunology , in vitro , biochemistry
The role of bioactive compounds in wound repair is critical. The preliminary work described herein includes the study of the effects of second degree burns in a Rex rabbit model and the action of human umbilical cord cells on the regulation and secretion of bioactive compounds. When applied on blood scaffolds as heterograft matrices, fibroblasts proliferate from these primary cultures and release biologically active peptides under tight control. Our work in progress indicates that mesenchymal stem cell (MSC)–mediated therapy provides better quality and more efficient burn reepithelialization of injured tissues by controlling the release of these peptides. Improvement of wound aesthetics is achieved in less time than without MSC‐mediated therapy. Well‐organized epidermal regeneration and overall better quality of reepithelialization, with no rejection, can be demonstrated consistently with periodic biopsies. Our studies indicate that MSCs have the capacity to produce, regulate, and deliver biologically active peptides that result in superior regeneration, compared with conventional treatments.