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Thymosin β4 sustained release from poly(lactide‐co‐glycolide) microspheres: synthesis and implications for treatment of myocardial ischemia
Author(s) -
Thatcher Jeffrey E.,
Welch Tré,
Eberhart Robert C.,
Schelly Zoltan A.,
Michael DiMaio J.
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06681.x
Subject(s) - microsphere , glycolic acid , plga , emulsion , thymosin , lactide , lactic acid , chemistry , myocardial ischemia , peptide , polymer , materials science , biomedical engineering , pharmacology , ischemia , nanotechnology , nanoparticle , chemical engineering , medicine , biochemistry , organic chemistry , copolymer , bacteria , engineering , genetics , biology
A sustained release formulation for the therapeutic peptide thymosin β4 (Tβ4) that can be localized to the heart and reduce the concentration and frequency of dose is being explored as a means to improve its delivery in humans. This review contains concepts involved in the delivery of peptides to the heart and the synthesis of polymer microspheres for the sustained release of peptides, including Tβ4. Initial results of poly(lactic‐co‐glycolic acid) microspheres synthesized with specific tolerances for intramyocardial injection that demonstrate the encapsulation and release of Tβ4 from double‐emulsion microspheres are also presented.