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Charge‐selective claudin channels
Author(s) -
Krug Susanne M.,
Günzel Dorothee,
Conrad Marcel P.,
Lee InFah M.,
Amasheh Salah,
Fromm Michael,
Yu Alan S. L.
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06555.x
Subject(s) - claudin , paracellular transport , tight junction , reabsorption , chemistry , microbiology and biotechnology , biophysics , sodium , biology , biochemistry , permeability (electromagnetism) , membrane , organic chemistry
Claudins are the main determinants of barrier properties of the tight junction. Many claudins have been shown to act by tightening the paracellular pathway, but several function as paracellular channels. While some depend on the endogenous claudin background of the analyzed cell line, for other claudins, a distinct charge‐selectivity has been shown. This paper portrays cation‐selective (claudin‐2, claudin‐10b, claudin‐15) and anion‐selective (claudin‐10a, claudin‐17) claudins and claudins with debatable channel properties (claudin‐4, claudin‐7, claudin‐16). It also describes molecular properties determining the observed charge‐selectivity and pore properties in general. In leaky tissues, they widely determine overall transport characteristics by providing paracellular ion‐selective pathways. In small intestine, claudin‐2 and claudin‐15 replace each other in the developing gut. In kidney proximal tubules, claudin‐2, claudin‐10, and claudin‐17 allow for paracellular reabsorption of sodium, chloride, and water.