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ZO‐2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis
Author(s) -
GonzalezMariscal Lorenza,
Bautista Pablo,
Lechuga Susana,
Quiros Miguel
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06537.x
Subject(s) - adherens junction , tight junction , microbiology and biotechnology , scaffold protein , occludin , wnt signaling pathway , guanylate kinase , cytoplasm , cytoskeleton , signal transduction , cell junction , apoptosis , actin , chemistry , signal transducing adaptor protein , actin cytoskeleton , cell growth , biology , cell , membrane protein , cadherin , biochemistry , membrane
ZO‐2 is a membrane‐associated guanylate kinase homologue (MAGUK) tight protein associated with the cytoplasmic surface of tight junctions. Here, we describe how ZO‐2 is a multidomain molecule that binds to a variety of cell signaling proteins, to the actin cytoskeleton, and to gap, tight, and adherens junction proteins. In sparse cultures, ZO‐2 is present at the nucleus and associates with molecules active in gene transcription and pre‐mRNA processing. ZO‐2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.