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Involvement of claudins in zebrafish brain ventricle morphogenesis
Author(s) -
Zhang Jingjing,
Liss Martin,
Wolburg Hartwig,
Blasig Ingolf E.,
AbdelilahSeyfried Salim
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2012.06507.x
Subject(s) - zebrafish , claudin , morphogenesis , ventricle , microbiology and biotechnology , biology , neuroepithelial cell , microvessel , hydrostatic pressure , blood–brain barrier , third ventricle , anatomy , tight junction , medicine , neuroscience , central nervous system , angiogenesis , stem cell , cancer research , neural stem cell , genetics , gene , physics , thermodynamics
Zebrafish brain ventricle morphogenesis involves an initial circulation‐independent opening followed by a blood flow– and circulation‐dependent expansion process. Zebrafish claudin‐5a is required for the establishment of a neuroepithelial–ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin‐3 and claudin‐5, are expressed within microvessel endothelial cells of the blood–brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.