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CD33‐related siglecs as potential modulators of inflammatory responses
Author(s) -
Crocker Paul R.,
McMillan Sarah J.,
Richards Hannah E.
Publication year - 2012
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06449.x
Subject(s) - siglec , immune system , receptor , microbiology and biotechnology , biology , inflammation , signal transduction , inhibitory postsynaptic potential , in vivo , immunology , neuroscience , biochemistry , genetics
The immune system must be tightly regulated to prevent unwanted tissue damage caused by exaggerated immune and inflammatory reactions. Inhibitory and activating immune receptors play a crucial role in this function via phosphotyrosine‐dependent signaling pathways. A significant body of evidence has accumulated suggesting that the siglec family of sialic acid binding Ig‐like lectins makes an important contribution to this immunoregulation. The CD33‐related siglecs are a distinct subset of inhibitory and activating receptors, expressed primarily on leukocytes in a cell type‐specific manner. Here, we critically assess the in vitro and in vivo evidence on the functional role for CD33‐related siglecs in modulation of inflammatory and immune responses.