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The osteoclast and its unique cytoskeleton
Author(s) -
Teitelbaum Steven L.
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06283.x
Subject(s) - osteoclast , microbiology and biotechnology , cytoskeleton , bone resorption , podosome , actin , chemistry , actin cytoskeleton , organelle , cell , biology , receptor , biochemistry , genetics
The osteoclast cytoskeleton is a unique structure that polarizes the cell's resorptive machinery to the bone–cell interface where it creates an isolated resorptive microenvironment consisting of an actin ring surrounding a ruffled border. This polarization process occurs under the aegis of the α v β 3 integrin in collaboration with the M‐CSF receptor, c‐Fms. When occupied, α v β 3 activates a canonical signaling complex consisting of c‐Src, Syk, Dap12, Slp76, Vav 3, and Rac that permits the cell to spread and form actin rings. Generation of the ruffled border, the cell's resorptive organelle, is an exocytic process wherein synaptotagmin VII mediates fusion of secretory lysosomes to the bone‐apposed plasma membrane. Absence of any component of this signaling pathway compromises osteoclast cytoskeletal organization and abridges bone resorption.