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Noninvasive imaging of bone microarchitecture
Author(s) -
Patsch Janina M.,
Burghardt Andrew J.,
Kazakia Galateia,
Majumdar Sharmila
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06282.x
Subject(s) - microarchitecture , magnetic resonance imaging , peripheral , high resolution , computer science , quantitative computed tomography , biomedical engineering , medicine , radiology , pathology , bone mineral , osteoporosis , geology , remote sensing , operating system
The noninvasive quantification of peripheral compartment‐specific bone microarchitecture is feasible with high‐resolution peripheral quantitative computed tomography (HR‐pQCT) and high‐resolution magnetic resonance imaging (HR‐MRI). In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses. Methodical limitations, morphometric parameter definition, and motion artifacts have to be considered to achieve optimal data interpretation from imaging studies. With increasing availability of in vivo high‐resolution bone imaging techniques, special emphasis should be put on quality control including multicenter, cross‐site validations. Importantly, conclusions from interventional studies investigating the effects of antiosteoporotic drugs on bone microarchitecture should be drawn with care, ideally involving imaging scientists, translational researchers, and clinicians.