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Epigenetic regulation of osteoclast differentiation
Author(s) -
Yasui Tetsuro,
Hirose Jun,
Aburatani Hiroyuki,
Tanaka Sakae
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06245.x
Subject(s) - h3k4me3 , nfat , demethylase , rankl , histone methylation , histone h3 , microbiology and biotechnology , epigenetics , histone , chemistry , biology , transcription factor , cancer research , dna methylation , activator (genetics) , gene expression , receptor , biochemistry , promoter , gene
Recent studies have uncovered that epigenetic regulation, such as histone methylation and acetylation, plays a critical role in determining cell fate. In particular, the expression of key developmental genes tends to be regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3). Osteoclasts are primary cells for bone resorption, and their differentiation is tightly regulated by the receptor activator of nuclear factor κB ligand (RANKL) and a transcription factor nuclear factor–activated T cell (NFAT) c1. We found that RANKL‐induced NFATc1 expression is associated with the demethylation of H3K27me3. Jumonji domain containing‐3, a H3K27 demethylase, is induced in bone marrow–derived macrophages in response to RANKL stimulation and may play a critical role in the demethylation of H3K27me3 in the Nfatc1 gene.