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Adrenergic stimulation decreases osteoblast oxytocin synthesis
Author(s) -
Cuscito Concetta,
Colaianni Graziana,
Tamma Roberto,
Greco Giovanni,
Dell’Endice Stefania,
Yuen Tony,
Sun Li,
Zaidi Mone,
Di Benedetto Adriana,
Zallone Alberta
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06235.x
Subject(s) - oxytocin , osteoblast , agonist , endocrinology , stimulation , adrenergic , medicine , chemistry , adrenergic receptor , receptor , antagonist , biology , in vitro , biochemistry
Oxytocin (OT) regulates bone mass by inducing the differentiation of osteoblasts to a mature, mineralizing phenotype. We have shown recently that osteoblasts can synthesize OT. In view of known interactions between OT‐ergic and adrenergic neurons in the central nervous system, we questioned whether the negative regulation of osteoblast differentiation by adrenergic nerves was mediated through its suppression of OT synthesis. We first confirmed that α 1b and β 2 adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3‐E1 cells. We then showed that α 1 and β 2 adrenergic agonists downregulated OT synthesis, and that the effect of each agonist was reversed by its respective antagonist. The data suggest that the negative effects of adrenergic stimulation on bone mass could, in part, arise from decreased OT synthesis.