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Combinatorial control of ATF4‐dependent gene transcription in osteoblasts
Author(s) -
StArnaud René,
Hekmatnejad Bahareh
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06197.x
Subject(s) - atf3 , atf4 , leucine zipper , transcription factor , basic helix loop helix leucine zipper transcription factors , microbiology and biotechnology , coactivator , sp3 transcription factor , activating transcription factor 2 , bzip domain , taf2 , biology , activating transcription factor , e box , chemistry , dna binding protein , gene , promoter , genetics , gene expression , enhancer
Osteoblast‐specific gene transcription requires interaction between bone cell–specific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain‐leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibited through interaction with other leucine zipper proteins, intermediate filament proteins, components of the basic transcriptional machinery, nuclear matrix attachment molecules, or ubiquitously expressed transcription factors. We discuss the results supporting the relevance of these interactions and present the first evidence of a functional interaction between ATF4, FIAT (factor‐inhibiting ATF4‐mediated transcription), and αNAC (nascent polypeptide‐associated complex and coactivator alpha), three proteins that have been previously shown to associate using various protein–protein interaction assays.