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Growth hormone–STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism
Author(s) -
Baik Myunggi,
Yu Ji Hoon,
Hennighausen Lothar
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06100.x
Subject(s) - stat protein , stat5 , hepatocellular carcinoma , hormone , cancer research , endocrinology , biology , transcription factor , signal transduction , medicine , cell growth , stat3 , microbiology and biotechnology , gene , biochemistry
The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH–STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH–STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH–STAT5 in sex‐specific gene expression and bile acid, steroid, and drug metabolism.