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Mendelian genetics of male infertility
Author(s) -
Hwang Kathleen,
Yatsenko Alexander N.,
Jorgez Carolina J.,
Mukherjee Sarmistha,
Nalam Roopa Lata,
Matzuk Martin M.,
Lamb Dolores J.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05917.x
Subject(s) - mendelian inheritance , sterility , offspring , infertility , biology , genetics , population , male infertility , reproductive success , sperm , lineage (genetic) , medicine , pregnancy , gene , environmental health
Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive‐age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infertile individual cannot be transmitted to the offspring, ensuring the maintenance of reproductive fitness of the species. However, with the advent of assisted reproductive techniques (ART), we are now able to overcome sterility and bypass nature's protective mechanisms that developed through evolution to prevent fertilization by defective or deficient sperm.