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The role of STAT5 in the development, function, and transformation of B and T lymphocytes
Author(s) -
HeltemesHarris Lynn M.,
Willette Mark J. L.,
Vang Kieng B.,
Farrar Michael A.
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05907.x
Subject(s) - stat5 , stat protein , transcription factor , repressor , function (biology) , microbiology and biotechnology , transcription (linguistics) , biology , cytokine , signal transduction , immunology , stat3 , gene , genetics , philosophy , linguistics
The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.