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Resveratrol modulates astroglial functions: neuroprotective hypothesis
Author(s) -
QuincozesSantos André,
Gottfried Carmem
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05857.x
Subject(s) - neuroprotection , resveratrol , glutamatergic , glutamate receptor , neuroscience , glutamine synthetase , central nervous system , nervous system , synaptic plasticity , glutathione , excitotoxicity , chemistry , biology , glutamine , pharmacology , biochemistry , enzyme , amino acid , receptor
Resveratrol, a redox active compound present in grapes and wine, has a wide range of biological effects, including cardioprotective, chemopreventive, and anti‐inflammatory activities. The central nervous system is a target of resveratrol, which can pass the blood–brain barrier and induce neuroprotective effects. Astrocytes are one of the most functionally diverse groups of cells in the nervous system, intimately associated with glutamatergic metabolism, transmission, synaptic plasticity, and neuroprotection. In this review, we focus on the resveratrol properties and response to oxidative insult on important astroglial parameters involved in brain plasticity, such as glutamate uptake, glutamine synthetase activity, glutathione content, and secretion of the trophic factor S100B.