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Neurokinin‐1 receptor: functional significance in the immune system in reference to selected infections and inflammation
Author(s) -
Douglas Steven D.,
Leeman Susan E.
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05826.x
Subject(s) - proinflammatory cytokine , immune system , receptor , g protein coupled receptor , biology , tachykinin receptor 1 , microbiology and biotechnology , inflammation , signal transduction , immunology , substance p , biochemistry , neuropeptide
The G protein–coupled receptor (GPCR), neurokinin‐1 receptor (NK1R), and its preferred ligand, substance P (SP), are reviewed in relationship to the immune system and selected infections. NK1R and SP are ubiquitous throughout the animal kingdom. This important pathway has unique functions in numerous cells and tissues. The interaction of SP with its preferred receptor, NK1R, leads to the activation of nuclear factor‐kappa B (NF‐κB) and proinflammatory cytokines. NK1R has two isoforms, both a full‐length and a truncated form. These isoforms have different functional significances and differ in cell signaling capability. The proinflammatory signals modulated by SP are important in bacterial, viral, fungal, and parasitic diseases, as well as in immune system function. The SP–NK1R system is a major class 1, rhodopsin‐like GPCR ligand–receptor interaction.