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MicroRNAs in cancer: personalizing diagnosis and therapy
Author(s) -
NanaSinkam S. Patrick,
Fabbri Muller,
Croce Carlo M.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05822.x
Subject(s) - microrna , cancer , suppressor , disease , biology , personalized medicine , bioinformatics , cancer research , precision medicine , pathogenesis , computational biology , medicine , gene , genetics , immunology , pathology
MicroRNAs (miRNAs) are 19–24nt noncoding RNAs that have been implicated in the pathogenesis of both solid and hematological malignancies. Frequently located in fragile chromosomal regions, miRNAs are essential to key biological functions, such as cellular differentiation, apoptosis, and growth. miRNAs may serve as either tumor suppressors or oncogenes. As a result, they have the potential to serve as both biomarkers and therapeutic agents in cancer. Based on our presentation at the recent Towards Personalized Cancer Medicine conference held in Barcelona, Spain, May 19–21, 2010, we provide an overview of the current knowledge of miRNA deregulation in solid and hematological malignancies and their application as biomarkers of disease.