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How inflammation modulates central nervous system vessel activation and provides targets for intervention—a personal perspective
Author(s) -
Hallenbeck John
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05785.x
Subject(s) - inflammation , medicine , neuroscience , central nervous system , stroke (engine) , innate immune system , blood vessel , immune system , spinal cord injury , immunology , spinal cord , psychology , mechanical engineering , engineering
I here describe a line of research that grew out of studies of spinal cord–damaging decompression sickness, focused on the blood–endothelial interface, that was influenced by the local Shwartzman phenomenon, addressed innate immune and inflammatory mechanisms, and ultimately arrived at mucosal tolerance approaches to prevent stroke. Intranasal instillation of E‐selectin is under development as a novel means of targeting immunomodulation to activating blood vessels within the vascular tree supplying the brain. The goal of this form of focused immunomodulation is to prevent recurrent strokes in patients that have previously suffered transient ischemic attacks or strokes.