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Measurement of inflammation and oxidative stress following drastic changes in air pollution during the Beijing Olympics: a panel study approach
Author(s) -
Kipen Howard,
Rich David,
Huang Wei,
Zhu Tong,
Wang Guangfa,
Hu Min,
Lu Shouen,
OhmanStrickland Pamela,
Zhu Ping,
Wang Yuedan,
Zhang Jim Junfeng
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05638.x
Subject(s) - beijing , air pollution , environmental health , oxidative stress , pollution , china , epidemiology , environmental protection , environmental science , medicine , biology , geography , pathology , ecology , archaeology
Ambient air pollution has been linked to cardiovascular and respiratory morbidity and mortality in epidemiology studies. Frequently, oxidative and nitrosative stress are hypothesized to mediate these pollution effects, however precise mechanisms remain unclear. This paper describes the methodology for a major panel study to examine air pollution effects on these and other mechanistic pathways. The study took place during the drastic air pollution changes accompanying the 2008 Olympics in Beijing, China. After a general description of air pollution health effects, we provide a discussion of panel studies and describe the unique features of this study that make it likely to provide compelling results. This study should lead to a clearer and more precise definition of the role of oxidative and nitrosative stress, as well as other mechanisms, in determining acute morbidity and mortality from air pollution exposure.