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Metabolic analysis of 13 C‐labeled pyruvate for noninvasive assessment of mitochondrial function
Author(s) -
Wu IChien,
Ohsawa Ikuroh,
Fuku Noriyuki,
Tanaka Masashi
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05636.x
Subject(s) - neurodegeneration , mitochondrion , metabolic activity , medicine , function (biology) , pyruvic acid , pyruvate dehydrogenase complex , metabolic pathway , chemistry , biochemistry , metabolism , biology , physiology , pathology , microbiology and biotechnology , disease , enzyme
Mitochondria may play important roles in metabolic diseases, neurodegeneration, and aging. Therefore, noninvasive methods to assess mitochondrial metabolic function in humans are urgently needed. We demonstrated that the 13 C‐breath test using [1‐ 13 C] acetate and [1‐ 13 C] pyruvate holds great potential for assessing the metabolic status in mitochondria. The 13 C‐breath test allows us to assess dynamic metabolic pathways noninvasively within 60 min. This test will not only facilitate clinical evaluation of patients but also provide huge opportunities for further understanding of these conditions. The potential of the 13 C‐breath test using 13 C‐labeled pyruvate in humans cannot be overemphasized.