Premium
Iron metabolism and ineffective erythropoiesis in β‐thalassemia mouse models
Author(s) -
Ramos Pedro,
Melchiori Luca,
Gardenghi Sara,
VanRoijen Nico,
Grady Robert W.,
Ginzburg Yelena,
Rivella Stefano
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05596.x
Subject(s) - erythropoiesis , ineffective erythropoiesis , anemia , thalassemia , limiting , hepcidin , disease , medicine , mechanical engineering , engineering
β‐thalassemia is a disease associated with decreased β‐globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically‐relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.