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Redefining thalassemia as a hypercoagulable state
Author(s) -
Cappellini M. Domenica,
Motta Irene,
Musallam Khaled M.,
Taher Ali T.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05548.x
Subject(s) - thalassemia , medicine , thrombosis , life expectancy , intermedia , intensive care medicine , incidence (geometry) , beta thalassemia , pediatrics , environmental health , population , physics , performance art , optics , art history , art
As the life expectancy of β‐thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.