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Ghrelin: more than endogenous growth hormone secretagogue
Author(s) -
Kojima Masayasu,
Kangawa Kenji
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05516.x
Subject(s) - ghrelin , growth hormone secretagogue receptor , endocrinology , appetite , medicine , energy homeostasis , hormone , endogeny , regulator , secretagogue , biology , biochemistry , obesity , secretion , gene
Since its discovery 10 years ago, intensive research has been performed on ghrelin. The significance of ghrelin as a growth hormone–releasing hormone, appetite regulator, energy conservator, and sympathetic nerve suppressor has now been well established. In this review, we summarize recent topics on ghrelin, such as the processing protease of the ghrelin precursor, ghrelin O ‐acyl transaferase, ghrelin knockout and transgenic mice, and the molecular mechanism of ghrelin's orexigenesis.