Premium
Hyperbaric oxygen treatment induces antioxidant gene expression
Author(s) -
Godman Cassandra A.,
Joshi Rashmi,
Giardina Charles,
Perdrizet George,
Hightower Lawrence E.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05393.x
Subject(s) - oxidative stress , hormesis , angiogenesis , antioxidant , downregulation and upregulation , reactive oxygen species , calorie restriction , wound healing , hyperbaric oxygen , microbiology and biotechnology , endothelial stem cell , pharmacology , gene expression , oxidative phosphorylation , cancer research , biology , gene , medicine , immunology , endocrinology , biochemistry , surgery , in vitro
Although the underlying molecular causes of aging are not entirely clear, hormetic agents like exercise, heat, and calorie restriction may generate a mild pro‐oxidant stress that induces cell protective responses to promote healthy aging. As an individual ages, many cellular and physiological processes decline, including wound healing and reparative angiogenesis. This is particularly critical in patients with chronic non‐healing wounds who tend to be older. We are interested in the potential beneficial effects of hyperbaric oxygen as a mild hormetic stress on human microvascular endothelial cells. We analyzed global gene expression changes in human endothelial cells following a hyperbaric exposure comparable to a clinical treatment. Our analysis revealed an upregulation of antioxidant, cytoprotective, and immediate early genes. This increase coincided with an increased resistance to a lethal oxidative stress. Our data indicate that hyperbaric oxygen can induce protection against oxidative insults in endothelial cells and may provide an easily administered hormetic treatment to help promote healthy aging.