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Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation
Author(s) -
Wysolmerski John J.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05249.x
Subject(s) - lactation , osteoporosis , offspring , bone remodeling , bone mineral , endocrinology , medicine , physiology , breast feeding , mammary gland , breast cancer , skeleton (computer programming) , breast milk , pregnancy , biology , cancer , anatomy , biochemistry , genetics , pediatrics
Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. As a result, lactation is associated with dramatic alterations in bone and mineral metabolism, including reversible bone loss. One theme that has emerged from recent studies examining these adaptations is that the lactating breast actively participates in regulating bone and mineral metabolism. This review will detail our current knowledge of interactions between the breast, skeleton, and hypothalamus during lactation and will consider implications that this reproductive physiology has for the pathophysiology of osteoporosis and breast cancer.