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Calmodulin—an often‐ignored signal in osteoclasts
Author(s) -
Williams John P.,
Micoli Keith,
McDonald Jay M.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05242.x
Subject(s) - calmodulin , signal (programming language) , computer science , chemistry , biophysics , microbiology and biotechnology , computational biology , biology , biochemistry , enzyme , programming language
Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review, the function of Ca 2+ /calmodulin signaling in osteoclast development, function, and apoptosis is reviewed. Considerable evidence supports an important regulatory role for Ca 2+ /calmodulin signaling in each of these processes. The overall role of Ca 2+ /calmodulin in regulating bone turnover is also supported by animal and human studies showing that calmodulin antagonists preserve bone mass.