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Posttranslational modifications of collagens as targets of hypoxia and Hif‐1α in endochondral bone development
Author(s) -
Schipani Ernestina
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05236.x
Subject(s) - microbiology and biotechnology , hypoxia (environmental) , endochondral ossification , transcription factor , chondrogenesis , mediator , biology , chemistry , oxygenation , hypoxia inducible factors , mesenchymal stem cell , cartilage , biochemistry , anatomy , oxygen , gene , ecology , organic chemistry
In recent years, it has been proposed that oxygen is not only an indispensable metabolic substrate, but also a regulatory signal, and that gradients of oxygenation turn on a specific genetic program. A crucial mediator of the adaptive response of cells to hypoxia is the transcription factor hypoxia‐inducible factor 1α (Hif‐1α). The fetal growth plate, which is an avascular structure of mesenchymal origin, has a unique out‐in gradient of oxygenation. Hif‐1α is required for chondrogenesis in vivo by controlling a complex homeostatic response that allows chondrocytes to survive and differentiate in an hypoxic environment. Preliminary evidence suggests that regulation of posttranslational modifications of collagens could be an important component of this adaptive response.