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iPS cell technology in regenerative medicine
Author(s) -
Lengner Christopher J.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05213.x
Subject(s) - induced pluripotent stem cell , regenerative medicine , sox2 , embryonic stem cell , klf4 , reprogramming , biology , somatic cell , stem cell , microbiology and biotechnology , cell , genetics , gene
The promise of treating human genetic and degenerative diseases through the application of pluripotent cell‐based tissue engineering and regenerative medicine has come significantly closer to realization since the isolation of human embryonic stem (ES) cells. While the study of ES cells has greatly increased our fundamental understanding of pluripotency, technical and ethical limitations have been seemingly insurmountable impediments to the application of these cells in the clinic. The recent discovery that somatic mammalian cells can be epigenetically reprogrammed to a pluripotent state through the exogenous expression of the transcription factors OCT4, SOX2, KLF4, and c‐MYC has yielded a new cell type for potential application in regenerative medicine, the induced pluripotent stem (iPS) cell. Here we discuss how advances in iPS cell technology have led to the generation of patient‐specific cell lines that can potentially be used to model human diseases and ultimately act as therapeutic agents.