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Blocking Interleukin‐1 in Rheumatic Diseases
Author(s) -
GoldbachMansky Raphaela
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05159.x
Subject(s) - anakinra , medicine , rheumatoid arthritis , immunology , proinflammatory cytokine , gout , arthritis , interleukin 1 receptor antagonist , disease , pathogenesis , receptor antagonist , receptor , inflammation , antagonist
The role of the potent proinflammatory cytokine IL‐1 in disease could clinically be investigated with the development of the IL‐1 blocking agent anakinra (Kineret ® ), a recombinant IL‐1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of patients with rheumatoid arthritis. More recently IL‐1 blocking therapies are used successfully to treat a new group of immune‐mediated inflammatory conditions, autoinflammatory diseases. These conditions include rare hereditary fever syndromes and pediatric and adult conditions of Still's disease. Recently the FDA approved two additional longer acting IL‐1 blocking agents, for the treatment of cryopyrin‐associated periodic syndromes (CAPS), an IL‐1 dependent autoinflammatory syndrome. The study of autoinflammatory diseases revealed mechanisms of IL‐1 mediated organ damage and provided concepts to a better understanding of the pathogenesis of more common diseases such as gout and Type 2 diabetes which show initial promising results with IL‐1 blocking therapy.