Premium
Cross‐presentation of peptides from intracellular pathogens by MHC class I molecules
Author(s) -
Blanchard Nicolas,
Shastri Nilabh
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05135.x
Subject(s) - major histocompatibility complex , biology , cross presentation , intracellular , intracellular parasite , mhc class i , microbiology and biotechnology , antigen presentation , cd8 , pathogen , immune system , computational biology , t cell , immunology
Many prokaryotic and eukaryotic parasites multiply in specialized subcellular niches in the host cell. The invading microbes hijack key cellular functions to establish the intracellular niches but, unlike viruses, do not need the protein synthesis machinery of host cells to replicate. Circulating CD8 + T cells provide protective immunity by recognizing pathogen‐derived peptide major histocompatibility complex class I molecules (pMHC I) expressed by infected cells. Here, we review studies on the complex and varied pathways that produce the appropriate pMHC I as ligands for the CD8 + T cells. We also discuss possible explanations for the curious observations that CD8 + T cells are specific for fewer pMHC I ligands in parasite infections compared to the diversity of pMHC I ligands in viral infections.