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New insights into T cell biology and T cell‐directed therapy for autoimmunity, inflammation, and immunosuppression
Author(s) -
StewardTharp Scott M.,
Song Yunjeong,
Siegel Richard M.,
O'Shea John J.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05124.x
Subject(s) - autoimmunity , immunosuppression , context (archaeology) , t cell , immunology , inflammation , cell therapy , biology , transplantation , medicine , cell , immune system , genetics , paleontology , surgery
T cell‐directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell‐directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.