Premium
Advances in the treatment of neurodegenerative disorders employing nanotechnology
Author(s) -
Modi Girish,
Pillay Viness,
Choonara Yahya E.
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05108.x
Subject(s) - neuroscience , drug delivery , nanotechnology , modalities , therapeutic modalities , medicine , computer science , psychology , materials science , social science , physical therapy , sociology
Due to limitations posed by the restrictive blood–brain barrier, conventional drug delivery systems do not provide adequate cyto‐architecture restoration and connection patterns that are essential for functional recovery in neurodegenerative disorders (NDs). Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of NDs by stimulating, responding to, and interacting with target sites to induce physiological responses while minimizing side effects. This review provides a concise discussion of the current applications of nano‐enabled drug‐delivery systems for the treatment of NDs, in particular Alzheimer's and Parkinson's diseases, and explores the future applications of nanotechnology in clinical neuroscience to develop innovative therapeutic modalities for the treatment of NDs.