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AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease
Author(s) -
Lovestone Simon,
Francis Paul,
Kloszewska Iwona,
Mecocci Patrizia,
Simmons Andrew,
Soininen Hilkka,
Spenger Christian,
Tsolaki Magda,
Vellas Bruno,
Wahlund LarsOlof,
Ward Malcolm
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05064.x
Subject(s) - biomarker discovery , biomarker , context (archaeology) , disease , alzheimer's disease , clinical trial , medicine , proteomics , bioinformatics , modalities , computational biology , neuroscience , data science , biology , computer science , pathology , genetics , paleontology , social science , sociology , gene
There is an urgent need for Alzheimer's disease (AD) biomarkers—especially in the context of clinical trials. Biomarkers for early diagnosis, disease progression, and prediction are most critical, and disease‐modification therapy development may depend on the discovery and validation of such markers. AddNeuroMed is a cross European, public/private consortium developed for AD biomarker discovery. We report here the development and design of AddNeuroMed and the progress toward the development of plasma markers. Despite the obstacles to such markers, we have identified a range of markers including CFH and A2M, both of which have been independently replicated. The experience of AddNeuroMed leads us to three overall conclusions. First, collaboration is essential. Second, design is paramount and combining modalities, such as imaging and proteomics, may be informative. Third, animal models are valuable in biomarker research. Most importantly, we have learned that plasma markers are feasible.