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Mitochondrial Metabolism and Cancer
Author(s) -
Weinberg Frank,
Chandel Navdeep S.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.05039.x
Subject(s) - citric acid cycle , mitochondrion , metabolism , glycolysis , cell cycle , nucleic acid metabolism , biochemistry , cell metabolism , cell growth , microbiology and biotechnology , chemistry , amino acid , biology , cell , rna , gene
Historically, it has been assumed that glycolytic metabolism, not mitochondrial metabolism, is essential for tumor cell proliferation. However, most tumor cells have functional mitochondria, and recent studies suggest that the citric acid cycle (TCA) cycle intermediates are precursors for synthesis of nucleotides, lipids, and amino acids. Here we review the accumulating evidence that mitochondrial metabolism plays an essential role in tumor cell proliferation.