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Perivascular Multipotent Progenitor Cells in Human Organs
Author(s) -
Crisan Mihaela,
Chen ChienWen,
Corselli Mirko,
Andriolo Gabriella,
Lazzari Lorenza,
Péault Bruno
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04967.x
Subject(s) - mesenchymal stem cell , cd90 , cd146 , microbiology and biotechnology , progenitor cell , stem cell , endothelial stem cell , biology , multipotent stem cell , cd34 , endoglin , stem cell transplantation for articular cartilage repair , pericyte , cd44 , adult stem cell , cell , in vitro , biochemistry , genetics
We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF‐Rβ, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo , sustained long‐term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.