Premium
Transformation from Committed Progenitor to Leukemia Stem Cells
Author(s) -
Krivtsov Andrei V.,
Feng Zhaohui,
Armstrong Scott A.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04966.x
Subject(s) - stem cell , progenitor cell , biology , haematopoiesis , leukemia , epigenetics , immunophenotyping , microbiology and biotechnology , chromosomal translocation , cancer research , genetics , gene , flow cytometry
Leukemias are composed of a hierarchy of cells, only a fraction of which have stem cell–like properties and are capable of self‐renewal. Mixed lineage leukemia (MLL) fusion proteins produced by translocations involving the MLL gene on chromosome 11q23 confer stem cell–like properties on committed hematopoietic progenitors. This provides an opportunity to assess changes in immunophenotype, gene expression, and epigenetic programs during the transition from a hematopoietic cell with minimal inherent self‐renewal capability to cells capable of leukemic self‐renewal.