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CSF Biomarkers
Author(s) -
Mattsson Niklas,
Blennow Kaj,
Zetterberg Henrik
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04944.x
Subject(s) - disease , pathological , pathogenesis , neuroscience , oxidative stress , medicine , amyloid (mycology) , inflammation , clinical practice , bioinformatics , pathology , biology , immunology , physical therapy
Intense research during the last decades has resulted in an unprecedented accumulation of knowledge regarding the pathogenesis of Alzheimer's disease. Primarily, the focus has been directed toward amyloid and tau pathology and their relations to synaptic and neuronal loss. However, as the complexity of the disease becomes increasingly evident, the importance of other factors, such as inflammation, oxidative stress, and mitochondrial dysfunction, grow apparent. Here, we review available CSF biomarkers for these pathological processes. We also consider their usability in clinical practice and in clinical trials.